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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11801327 B1

PDFFull Text
Date of Patent:
Oct. 31, 2023

Filed:

Apr. 22, 2021

Integrated organ and tissue printing methods, system and apparatus

Applicant:

Wake Forest University Health Sciences, Winston-Salem, NC (US);

Inventors:

Hyun-Wook Kang, Winston-Salem, NC (US);

Sang Jin Lee, Winston-Salem, NC (US);

Anthony Atala, Winston-Salem, NC (US);

James J. Yoo, Winston-Salem, NC (US);

Assignee:

WAKE FOREST UNIVERSITY HEALTH SCIENCES, Winston-Salem, NC (US);

Attorney:

Myers Bigel, P.A.

Primary Examiner:

Anh T Vo

Int. Cl.
CPC ...
A61L 27/20 (2006.01); A61L 27/22 (2006.01); A61L 27/26 (2006.01); A61L 27/38 (2006.01); A61L 27/52 (2006.01); B29C 64/112 (2017.01); B29C 64/124 (2017.01); B29C 64/393 (2017.01); B33Y 70/00 (2020.01); C12M 3/00 (2006.01); C12M 1/00 (2006.01); C12M 1/26 (2006.01); A61K 35/12 (2015.01); B33Y 10/00 (2015.01); B33Y 30/00 (2015.01); B33Y 80/00 (2015.01); B29K 105/00 (2006.01); B29K 267/00 (2006.01); B29L 31/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/20 (2013.01); A61L 27/222 (2013.01); A61L 27/225 (2013.01); A61L 27/26 (2013.01); A61L 27/38 (2013.01); A61L 27/52 (2013.01); B29C 64/112 (2017.08); B29C 64/124 (2017.08); B29C 64/393 (2017.08); B33Y 70/00 (2014.12); A61K 35/12 (2013.01); B29K 2105/0005 (2013.01); B29K 2267/04 (2013.01); B29L 2031/7532 (2013.01); B33Y 10/00 (2014.12); B33Y 30/00 (2014.12); B33Y 80/00 (2014.12); C12M 21/08 (2013.01); C12M 23/50 (2013.01); C12M 33/00 (2013.01);
Abstract

A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.

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