The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2023
Filed:
Dec. 13, 2018
Applicant:
The Trustees of Columbia University IN the City of New York, New York, NY (US);
Inventors:
Umrao Monani, Oradell, NJ (US);
Jeong Ki-Kim, Fort Lee, NJ (US);
Assignee:
The Trustees of Columbia University in the City of New York, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 35/761 (2015.01); A61K 38/46 (2006.01); A61P 21/00 (2006.01); C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); A61K 9/0019 (2013.01); A61K 9/0085 (2013.01); A61K 35/761 (2013.01); A61K 38/465 (2013.01); A61P 21/00 (2018.01); C12N 15/113 (2013.01); A61K 48/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01);
Abstract
The present disclosure provides compositions and methods of treating motor neuron diseases, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). A modulator of a heat shock protein, such as an Hsp70 family member protein, may be used in the present method. Alternatively, a mutant heat shock protein may be used.