The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2023
Filed:
Mar. 05, 2020
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Guido Marcucci, Duarte, CA (US);
Bin Zhang, Duarte, CA (US);
Ya-Huei Kuo, Duarte, CA (US);
Marcin Tomasz Kortylewski, Monrovia, CA (US);
Assignee:
CITY OF HOPE, Duarte, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2015.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C12N 15/113 (2013.01);
Abstract
Provided herein are, inter alia, methods of treating red blood cell disorders and cancer using anti-miR126 compounds. The methods include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence to treat red blood cell disorders. Other methods provided herein include administering phosphorothioated CpG oligodeoxynucleotides conjugated to an anti-miR126 nucleic acid sequence and a tyrosine kinase inhibitor to treat cancer.