The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
Oct. 11, 2019
Gna Biosolutions Gmbh, Planegg/Martinsried, DE;
Federico Buersgens, Planegg/Martinsried, DE;
Joachim Stehr, Planegg/Martinsried, DE;
Lars Ullerich, Planegg/Martinsried, DE;
Cecilia Rebuffo-Scheer, Planegg-Martinsried, DE;
HP HEALTH SOLUTIONS GERMANY GMBH, Martinsried, DE;
Abstract
One or more nanoparticles, each of which is conjugated with at least one oligonucleotide, are used to multiply nucleic acids. One or more of the oligonucleotides has at least one primer sequence and an additional segment extending from the end of the primer sequence proximal to the nanoparticle in the direction of the nanoparticle, and the additional segment has at least one abasic modification. The disclosed method for multiplying nucleic acids has a multiplication step and a test step for determining the concentration of the products of the multiplication reaction. The test step begins after the multiplication step ends, and in the test step, either at least one part of the sample is supplied with substances or no substances are supplied. In a method for multiplying nucleic acids, nanoparticles transfer heat into their surroundings in a reaction volume upon being excited. A method for multiplying a nucleic acid has an amplification step that uses a polymerase chain reaction, where a cycle consisting of the steps of denaturing, annealing, and elongating is repeated.