The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
Sep. 05, 2021
Ramot AT Tel-aviv University Ltd., Tel Aviv, IL;
Yeda Research and Development Co. Ltd., Rehovot, IL;
Synvaccine Ltd., Tel Aviv, IL;
Tamir Tuller, Herzeliya Pituach, IL;
Eli Goz, Herzlia, IL;
Shimshi Atar, Kiryat-Ono, IL;
Hadas Zur, Tel-Aviv, IL;
RAMOT AT TEL-AVIV UNIVERSITY LTD., Tel Aviv, IL;
YEDA RESEARCH AND DEVELOPMENT CO. LTD., Rehovot, IL;
SYNVACCINE LTD., Tel Aviv, IL;
Abstract
Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.