The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
May. 04, 2016
Applicant:
Mesoblast International Sàrl, Meyrin, CH;
Inventors:
Assignee:
MESOBLAST INTERNATIONAL SÁRL;, Meyrin, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0775 (2010.01); G01N 33/68 (2006.01); A61K 35/28 (2015.01); A61K 47/36 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0663 (2013.01); A61K 35/28 (2013.01); A61K 47/36 (2013.01); G01N 33/6863 (2013.01); C12N 2500/30 (2013.01); G01N 2333/495 (2013.01);
Abstract
The present invention relates to a method for determining the biological activity or therapeutic efficacy of cultured mesenchymal lineage precursor cells or stem cells based on their released TGF-9 levels in culture. The present invention also relates to isolated populations of mesenchymal lineage precursor cells or stem cells selected based on the level of TGF-9 levels released by such cells in culture. The present invention further relates to treatment of a subject suffering from a degenerative disc disease by administering such selected cell populations.