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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11795434 B1

PDFFull Text
Date of Patent:
Oct. 24, 2023

Filed:

Nov. 08, 2019

Engineered stem cells and cellular products produced and secreted by such cells, methods of preparing, and uses thereof

Applicants:

Ottawa Heart Institute Research Corporation, Ottawa, CA;

L'institut DE Cardiologie DE Montréal, Montréal, CA;

Inventors:

Patrick Vigneault, Montreal, CA;

Darryl Davis, Ottawa, CA;

Stanley Nattel, Montréal, CA;

Sandrine Parent, Ottawa, CA;

Assignees:

Ottawa Heart Institute Research Corporation, Ottawa, CA;

L'Institut de Cardiologie de Montréal, Montréal, CA;

Attorney:

Nyemaster Goode, P.C.

Primary Examiner:

Thane Underdahl

Int. Cl.
CPC ...
C12N 5/0775 (2010.01); A61K 35/34 (2015.01); A61K 35/12 (2015.01); A61P 9/00 (2006.01); C12P 1/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0662 (2013.01); A61K 35/12 (2013.01); A61K 35/34 (2013.01); A61P 9/00 (2018.01); C12N 15/86 (2013.01); C12P 1/00 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15043 (2013.01);
Abstract

There is disclosed a cardiac explant-derived stem cell (EDC), the cell comprising a gene encoding an intermediate-conductance Ca-activated Kchannel, and wherein the gene causes an overexpression of the intermediate-conductance Ca-activated Kchannel, and methods of producing same. There is also disclosed a method of producing engineered EDCs having a modulated bioelectric property, the method comprising: obtaining EDCs; introducing a KCNN4 gene into the EDCs to increase the expression of KCa3.1 channels, to produce engineered EDCs. There is also disclosed a composition for treating or ameliorating a damaged myocardium in a subject, the composition comprising extracellular vesicles isolated from cultures of engineered EDCs. There is also disclosed a method for treating or ameliorating a damaged myocardium in a subject, comprising administering the engineered EDCs or the extracellular vesicles isolated from cultures of engineered EDCs to the damaged myocardium of the subject.

Find Patent Forward Citations

Vigneault, Patrick. (2023). Engineered stem cells and cellular products produced and secreted by such cells, methods of preparing, and uses thereof (U.S. Patent No. 11795434). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11795434

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