The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
Aug. 03, 2021
Applicant:
Crispr Therapeutics Ag, Zug, CH;
Inventors:
Lalit Kumar, Cambridge, MA (US);
Mary-Lee Dequeant, Cambridge, CA (US);
Assignee:
CRISPR Therapeutics AG, Zug, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/42 (2006.01); C07K 16/46 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/4266 (2013.01); G01N 33/6854 (2013.01); C07K 2317/76 (2013.01); G01N 2333/70575 (2013.01);
Abstract
High affinity antibodies capable of binding to a single-chain variable fragment (scFv) of anti-CD70 antibody, for example, the scFv expressed on cell surface as a portion of a chimeric antigen receptor (CAR). Also provided herein are methods for producing such anti-scFv antibodies and methods of using the antibodies disclosed herein for detecting, for example, T cells expressing an anti-CD70 CAR that comprise the scFv as an extracellular domain.