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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11795231 B1

PDFFull Text
Date of Patent:
Oct. 24, 2023

Filed:

Feb. 11, 2022

Antagonistic cd40 monoclonal antibodies and uses thereof

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Aaron Yamniuk, Vancouver, CA;

Mary Struthers, Edison, NJ (US);

Stanley R. Krystek, Jr., Ringoes, NJ (US);

Akbar Nayeem, Newtown, PA (US);

Ginger Rakestraw, Somerville, MA (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:

Banner & Witcoff, LTD.

Primary Examiner:

Zachary C Howard

Int. Cl.
CPC ...
C12N 15/63 (2006.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); C07K 16/46 (2006.01); A61P 37/00 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 39/3955 (2013.01); A61K 47/68 (2017.08); A61K 47/6849 (2017.08); A61P 37/00 (2018.01); C07K 16/468 (2013.01); C12N 15/63 (2013.01); A61K 45/06 (2013.01); A61K 47/6803 (2017.08); A61K 2039/505 (2013.01); C07K 14/70578 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/71 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

The disclosure provides for antibodies that bind CD40, including a humanized antibody. The antibodies bind CD40 and do not exhibit CD40 agonist activity. The antibodies may comprise a modified IgG1 Fc domain, and exhibit minimal activation of immature dendritic cells. Compositions comprising antibodies, methods of use for treatment of diseases involving CD40 activity, and use in the preparation of a medicament for treatment of a disease involving CD40 activity are provided.

Find Patent Forward Citations

Yamniuk, Aaron. (2023). Antagonistic cd40 monoclonal antibodies and uses thereof (U.S. Patent No. 11795231). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11795231

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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