The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
Apr. 30, 2019
Applicant:
Genmab A/s, Copenhagen V, DK;
Inventors:
Assignee:
GENMAB A/S, Valby, DK;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/00 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 16/00 (2013.01); G01N 33/5014 (2013.01); G01N 33/6854 (2013.01); C07K 2317/51 (2013.01); C07K 2317/52 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/734 (2013.01);
Abstract
Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described.