The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
May. 11, 2022
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Jeffrey C. Boyington, Clarksburg, MD (US);
Barney S. Graham, Smyrna, GA (US);
John R. Mascola, Rockville, MD (US);
Hadi M. Yassine, Doha, QA;
Kizzmekia S. Corbett, Wheaton, MD (US);
Syed M. Moin, Laurel, MD (US);
Lingshu Wang, North Potomac, MD (US);
Masaru Kanekiyo, Chevy Chase, MD (US);
Abstract
Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.