The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 24, 2023

Filed:

Sep. 27, 2018
Applicants:

Inmune Bio Inc., La Jolla, CA (US);

Emory University, Atlanta, GA (US);

Inventors:

Maria Elizabeth De Souza Rodrigues, Atlanta, GA (US);

Maria de Lourdes Gamez Tansey, Atlanta, GA (US);

Christopher J. Barnum, Detroit, MI (US);

Raymond J. Tesi, Martha's Vineyard, MA (US);

Dean P. Jones, Atlanta, GA (US);

Douglas I. Walker, Atlanta, GA (US);

Assignees:

INmune Bio Inc, Boca Raton, FL (US);

EMORY UNIVERSITY, Atlanta, GA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 3/10 (2006.01); A61K 35/28 (2015.01); A61K 48/00 (2006.01); C07K 14/525 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 48/005 (2013.01); A61P 3/10 (2018.01); C07K 14/525 (2013.01); G01N 33/68 (2013.01); A61K 38/00 (2013.01); G01N 2333/82 (2013.01);
Abstract

The disclosure concerns a method of treating complications of acute or chronic hyperglycemia and/or diet-induced obesity comprising: (i) determining whether a patient suffers from complications related to acute or chronic hyperglycemia and/or diet induced obesity, and if so, (ii) administering to the patient in need thereof a selective inhibitor of soluble TNF-α but not transmembrane TNF-α. For purposes herein, complications of acute or chronic hyperglycemia and/or diet-induced obesity include: diabetes mellitus, insulin resistance, hepatic steatosis, non-alcoholic hepatic steatosis, fibrotic liver disease, vascular disease, and chronic intestinal inflammation.


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