The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
Nov. 30, 2017
Applicant:
Juno Therapeutics, Inc., Seattle, WA (US);
Inventor:
Hyam I. Levitsky, Seattle, WA (US);
Assignee:
Juno Therapeutics, Inc., Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61J 1/10 (2006.01); C07K 16/28 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61J 1/10 (2013.01); C07K 16/28 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); A61K 45/06 (2013.01); C12N 2015/8518 (2013.01);
Abstract
Provided herein are engineered B cells, such as for adoptive cell therapy. In some aspects, also provided are methods and compositions for engineering and producing the cells, compositions containing the cells, and methods for their administration to subjects. In some embodiments, the cells are engineered to produce and/or secrete an exogenous protein, such as a therapeutic protein, including antibodies and antigen-binding fragments thereof. In some aspects, features of the cells and methods provide for increased or improved activity, efficacy and/or persistence of the cells.