The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11793808 B1

Date of Patent:

Oct. 24, 2023

Filed:

Feb. 22, 2021

Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them

Applicant:

Mannkind Corporation, Westlake Villiage, CA (US);

Inventors:

Thomas Hofmann, Doylestown, PA (US);

Stefan Ufer, Raleigh, NC (US);

Kevin Stapleton, Laguna Beach, CA (US);

Assignee:

MANNKIND CORP., Westlake Village, CA (US);

Attorney:

Primary Examiner:

John S Kenyon

Int. Cl.

CPC ...

A61K 31/498 (2006.01); A61K 9/10 (2006.01); A61K 31/47 (2006.01); A61K 47/02 (2006.01); A61K 9/00 (2006.01); A61K 47/26 (2006.01);

U.S. Cl.

CPC ...

A61K 31/498 (2013.01); A61K 9/008 (2013.01); A61K 9/10 (2013.01); A61K 31/47 (2013.01); A61K 47/02 (2013.01); A61K 47/26 (2013.01);

Abstract

The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of a suspension, and processes for their preparation. Furthermore, the present invention provides pharmaceutical combinations comprising clofazimine in the form of an aerosol for pulmonary inhalation. The combinations and compositions provided by the present invention may be used in the treatment and/or prophylaxis of pulmonary infections caused by mycobacteria and other gram-positive bacteria, and of pulmonary fungal infections.

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