The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2023
Filed:
Oct. 03, 2017
University of South Florida, Tampa, FL (US);
The Regents of the University of California, Oakland, CA (US);
The Texas A&m University System, College Station, TX (US);
Edwin John Weeber, Apollo Beach, FL (US);
David J. Segal, Davis, CA (US);
Henriette O'Geen, Davis, CA (US);
Benjamin Pyles, Davis, CA (US);
Scott V. Dindot, College Station, TX (US);
UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
THE TEXAS A&M UNIVERSITY SYSTEM, College Station, TX (US);
Abstract
The present invention concerns non-human animals with cells having a genome that is lacking the entire E3 ubiquitin ligase (Ube3a) gene (including all isoforms and alternative promoters). These animals are useful for modeling Angelman Syndrome. The invention also includes methods for assessing the effect of an agent, such as potential therapeutics, on an animal model by exposing the animal or cells, tissues, or organs isolated therefrom, to an agent of interest.