The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Jun. 19, 2020
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Briana Martinez, Tempe, AZ (US);
Sarah Stabenfeldt, Tempe, AZ (US);
Chris Diehnelt, Chandler, AZ (US);
Nicholas Stephanopoulos, Scottsdale, AZ (US);
Crystal Willingham, Tempe, AZ (US);
Amanda Witten, Phoenix, AZ (US);
Kendall Lundgreen, Gilbert, AZ (US);
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Abstract
A unique pipeline is employed for biomarker discovery that entailed domain antibody phage display, next generation sequencing analysis, and nanotechnology strategies to generate antibody mimetics are disclosed. Also disclosed are the temporal biomarkers of traumatic brain injury and their methods of use. In some embodiments, the temporal biomarkers are synthetic peptides comprising the HCDR3 sequences identified using the disclosed pipeline. In some aspects, the synthetic peptides have less than 30 amino acid residues and comprise a biotin scaffold that is linked to the HCDR3 sequences.