The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Dec. 23, 2020
Applicant:
Boston Medical Center Corporation, Boston, MA (US);
Inventors:
Gustavo Mostoslavsky, Boston, MA (US);
Dar Heinze, Chelmsford, MA (US);
Assignee:
BOSTON MEDICAL CENTER CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C12N 5/0636 (2013.01); C12N 5/0646 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01);
Abstract
The technology described herein relates to compositions and methods for the generation of a primordial NK/T cell, where the produced NK/T primordial cell can subsequently differentiate into T cells or NK cells at an extremely high efficiency and reproducibility. Other aspects relate to genetically modified iPSC cell lines, and method of their use to generate iPSC-derived NK/T primordial cells with a very high yield and high efficiency.