The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Sep. 01, 2022
Dragonfly Therapeutics, Inc., Waltham, MA (US);
Ann F. Cheung, Lincoln, MA (US);
Jean-Marie Cuillerot, Somerville, MA (US);
Asya Grinberg, Lexington, MA (US);
Eva Gutierrez, Waltham, MA (US);
William Haney, Wayland, MA (US);
Nicolai Wagtmann, Concord, MA (US);
Dragonfly Therapeutics, Inc., Waltham, MA (US);
Abstract
The present invention provides Fc-fused protein constructs, which as monovalent dimers have a higher serum half-life compared to a native/natural molecule, and are, therefore, advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are Fc-fused protein constructs having mutations in the Fc region that reduce effector functions, which have increased activity to inhibit tumor growth and are, therefore, advantageous when used as a cancer therapy.