The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Jun. 22, 2018
Systimmune, Inc., Redmond, WA (US);
Sichuan Baili Pharmaceutical Co. Ltd., Chengdu, CN;
Yi Zhu, Chengdu, CN;
Ole Olsen, Everett, WA (US);
Dong Xia, Redmond, WA (US);
David Jellyman, Duvall, WA (US);
Katrina Bykova, Seattle, WA (US);
Anne-Marie K. Rousseau, Seattle, WA (US);
Bill Brady, Bothell, WA (US);
Blair Renshaw, Renton, WA (US);
Brian Kovacevich, Snohomish, WA (US);
Yu Liang, Redmond, WA (US);
Zeren Gao, Redmond, WA (US);
BAILI-BIO (CHENGDU) PHARMACEUTICAL CO., LTD., Chengdu, CN;
Abstract
The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a Fab domain, a Fc domain, a second scFv domain, and a third scFv at the C-terminal, wherein the first scFv domain, the Fab domain, the second scFv domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.