The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Sep. 23, 2016
Applicant:
Imcyse SA, Liège, BE;
Inventors:
Assignee:
IMCYSE SA, Liège, BE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/12 (2015.01); A61K 8/60 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/22 (2006.01); A61K 38/36 (2006.01); A61K 39/00 (2006.01); C12N 9/02 (2006.01); C07K 14/74 (2006.01); A61K 39/39 (2006.01); A61K 35/17 (2015.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70539 (2013.01); A61K 39/001 (2013.01); A61K 39/39 (2013.01); C12N 9/0004 (2013.01); A61K 38/00 (2013.01); A61K 2035/122 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/572 (2013.01); A61K 2039/627 (2013.01); A61K 2039/70 (2013.01); C07K 2319/40 (2013.01);
Abstract
The invention describes kit of parts of polypeptides comprising: a) a peptide comprising: a1) an MHC class II T cell epitope or a CD1 d-restricted NKT cell epitope, and a2) immediately adjacent to said epitope or separated by at most 7 amino acids from said epitope a [CST]-X(2)-C [SEQ ID NO:7] or C-X(2)-[CST] [SEQ ID NO:8] oxidoreductase motif sequence, and b) a polypeptide comprising: b1) a therapeutic protein and b2) the epitope defined in a1), wherein the epitope sequence is a sequence which differs from the sequence of the protein of b1). The therapeutic protein, in combination with the peptide, is used to prevent an immune response against the therapeutic protein.