The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Mar. 14, 2022
Novartis Ag, Basel, CH;
Simone Bonazzi, Cambridge, MA (US);
Artiom Cernijenko, Cambridge, MA (US);
Jennifer Stroka Cobb, Stow, MA (US);
Natalie Alysia Dales, Arlington, MA (US);
Janetta Dewhurst, Framingham, MA (US);
Matthew James Hesse, Oakland, CA (US);
Rama Jain, Danville, CA (US);
John Ryan Kerrigan, Wakefield, MA (US);
Hasnain Ahmed Malik, Boston, MA (US);
James R. Manning, Emeryville, CA (US);
Gary O'Brien, Maynard, MA (US);
Andrew W. Patterson, Somerville, MA (US);
Noel Marie-France Thomsen, Chelmsford, MA (US);
Pamela Y F Ting, Somerville, MA (US);
NOVARTIS AG, Basel, CH;
Abstract
The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.