The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Jun. 25, 2021
Applicant:
Incyte Corporation, Wilmington, DE (US);
Inventors:
Zhongjiang Jia, Kennett Square, PA (US);
William Frietze, Kenneth Square, PA (US);
Assignee:
Incyte Corporation, Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/14 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 403/14 (2013.01); C07D 403/12 (2013.01); C07B 2200/13 (2013.01);
Abstract
The present invention relates to salt forms of the hematopoietic progenitor kinase 1 (HPK1) inhibitors N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-5-fluorophenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide and N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-4-(4-cyanopyridin-3-yl)phenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide, including methods of preparation thereof, where the compounds are useful in the treatment of HPK1 mediated diseases such as cancer.