The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 17, 2023

Filed:

Mar. 30, 2021
Applicant:

North Carolina State University, Raleigh, NC (US);

Inventors:

Zhen Gu, Raleigh, NC (US);

Yanqi Ye, Raleign, NC (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61M 37/00 (2006.01); A61K 38/28 (2006.01); A61K 9/00 (2006.01); A61K 38/47 (2006.01); A61K 38/44 (2006.01); A61K 47/36 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61M 37/0015 (2013.01); A61K 9/0021 (2013.01); A61K 38/28 (2013.01); A61K 38/44 (2013.01); A61K 38/47 (2013.01); A61K 47/36 (2013.01); A61M 37/00 (2013.01); C12N 5/0677 (2013.01); C12Y 101/03004 (2013.01); C12Y 302/01001 (2013.01); C12Y 302/01003 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); A61M 2202/07 (2013.01); A61M 2230/201 (2013.01);
Abstract

Disclosed herein are microneedle devices, kits comprising the microneedle devices, and methods of using the microneedle devices. Specifically, disclosed is a device for transport of a material across a biological barrier of a subject comprising: a plurality of microneedles each having a base end and a tip, with at least one pathway disposed at or between the base end and the tip; a substrate to which the base ends of the microneedles are attached or integrated; and at least one reservoir which is in connection with the base ends of the microneedles array, wherein the reservoir comprises an agent delivery system, wherein the agent delivery system comprises an agent to be transported across the biological barrier, or a means for producing an agent to be transported across the biological barrier, and a means for detecting a physiological signal from the recipient.


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