The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Mar. 01, 2021
Musculoskeletal Transplant Foundation, Edison, NJ (US);
Eric Semler, Morganville, NJ (US);
Mark Spilker, Kilchberg, CH;
Kevin Wu, Morganville, NJ (US);
Yen-Chen Huang, East Brunswick, NJ (US);
Evangelia Chnari, Scotch Plains, NJ (US);
Jeffrey Cartmell, Freehold, NJ (US);
Morris Jacobs, Newton, NJ (US);
Alison Ling, Piscataway, NJ (US);
Moon Hae Sunwoo, Old Tappan, NJ (US);
Musculoskeletal Transplant Foundation, Edison, NJ (US);
Abstract
Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.