The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Jun. 14, 2011
Barbara Pui Chan, Hong Kong, HK;
Hiu WA Cheng, Hong Kong, HK;
Daniel Tsz Kit Chik, Hong Kong, HK;
Kenneth Man Chee Cheung, Hong Kong, HK;
Keith Dip Kei Luk, Hong Kong, HK;
Barbara Pui Chan, Hong Kong, HK;
Hiu Wa Cheng, Hong Kong, HK;
Daniel Tsz Kit Chik, Hong Kong, HK;
Kenneth Man Chee Cheung, Hong Kong, HK;
Keith Dip Kei Luk, Hong Kong, HK;
VERSITECH LIMITED, Hong Kong, CN;
Abstract
A simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue.