The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Sep. 07, 2021
The Regents of the University of Michigan, Ann Arbor, MI (US);
Jolanta Grembecka, Ann Arbor, MI (US);
Szymon Klossowski, Ann Arbor, MI (US);
Jing Deng, Ann Arbor, MI (US);
Tomasz Cierpicki, Ann Arbor, MI (US);
Hao Li, Ann Arbor, MI (US);
Hongzhi Miao, Ann Arbor, MI (US);
Trupta Purohit, Ann Arbor, MI (US);
EunGi Kim, Ann Arbor, MI (US);
Dong Chen, Ann Arbor, MI (US);
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Abstract
Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.