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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11786597 B1

PDFFull Text
Date of Patent:
Oct. 17, 2023

Filed:

Jun. 21, 2019

Ionic liquids for transdermal drug delivery

Applicants:

The Regents of the University of California, Oakland, CA (US);

Triad National Security, Llc, Los Alamos, NM (US);

Arizona Board of Regents, Flagstaff, AZ (US);

Inventors:

Michael Zakrewsky, San Diego, CA (US);

Samir Mitragotri, Lexington, MA (US);

David T. Fox, Los Alamos, NM (US);

Andrew Koppisch, Flagstaff, AZ (US);

Rico Del Sesto, Ivins, UT (US);

Katherine Lovejoy, Silver Spring, MD (US);

Assignees:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);

TRIAD NATIONAL SECURITY, LLC, Los Alamos, NM (US);

THE ARIZONA BOARD OF REGENTS, Flagstaff, AZ (US);

Attorney:

Pabst Patent Group LLP

Primary Examiner:

Layla Soroush

Int. Cl.
CPC ...
A01N 3/00 (2006.01); A61K 31/215 (2006.01); A01N 37/12 (2006.01); A01N 37/44 (2006.01); A61K 31/24 (2006.01); A01N 25/00 (2006.01); A61K 47/24 (2006.01); A61K 9/00 (2006.01); A61K 47/12 (2006.01); A01N 33/12 (2006.01); A01N 43/36 (2006.01); A61K 31/047 (2006.01); A61K 31/545 (2006.01); A61K 31/66 (2006.01);
U.S. Cl.
CPC ...
A61K 47/24 (2013.01); A01N 33/12 (2013.01); A01N 43/36 (2013.01); A61K 9/0014 (2013.01); A61K 31/047 (2013.01); A61K 31/545 (2013.01); A61K 31/66 (2013.01); A61K 47/12 (2013.01);
Abstract

The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.

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