The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Feb. 28, 2020
Applicant:
Allogene Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Regina Junhui Lin, San Mateo, CA (US);
Thomas John Van Blarcom, Oakland, CA (US);
Siler Panowski, Berkeley, CA (US);
Barbra Johnson Sasu, San Francisco, CA (US);
Assignee:
ALLOGENE THERAPEUCTICS, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/715 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 35/17 (2015.01); C12N 15/67 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C07K 14/7155 (2013.01); C07K 16/2818 (2013.01); C07K 16/30 (2013.01); C12N 15/67 (2013.01); A61K 38/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01);
Abstract
Provided herein are PD-1 chimeric cytokine receptors. When present on chimeric antigen receptor (CAR)-bearing immune cells, such receptors allow for increased immune cell activation, proliferation, persistence, and/or potency, when engaged with PD-1 ligands or activation with an anti-PD-1 antibody. Also provided are methods of making and using the chimeric cytokine receptors described herein.