logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11786544 B1

PDFFull Text
Date of Patent:
Oct. 17, 2023

Filed:

Apr. 15, 2021

Formulations of phosphoramidate derivatives of nucleoside drugs

Applicant:

Nucana Plc, Edinburgh, GB;

Inventors:

Gordon Kennovin, Edinburgh, GB;

Hugh Griffith, Edinburgh, GB;

Assignee:

NuCana plc, Edinburgh, GB;

Attorney:

Knowles Intellectual Property Strategies, LLC

Primary Examiner:

Patrick T Lewis

Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/7076 (2006.01); A61K 9/00 (2006.01); A61K 47/18 (2017.01); A61K 47/20 (2006.01); A61K 9/08 (2006.01); A61K 31/7072 (2006.01); A61P 35/02 (2006.01); A61K 47/22 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7076 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 31/7072 (2013.01); A61K 47/18 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61P 35/02 (2018.01);
Abstract

This invention relates to pharmaceutical formulations and formulation strategies of protides (phosphoramidate derivatives of nucleosides) and, in particular, protides useful in the treatment of cancer such as NUC-3373 (5-fluoro-2'-deoxyuridine-5′-O-[1-naphthyl (benzoxy-L-alaninyl)] phosphate) and NUC-7738 (3′-deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)] phosphate). In particular, the invention relates to formulations which comprise a polar aprotic solvent, for example dimethyl acetamide (DMA).

Find Patent Forward Citations

Kennovin, Gordon. (2023). Formulations of phosphoramidate derivatives of nucleoside drugs (U.S. Patent No. 11786544). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11786544

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…