The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2023
Filed:
Jan. 23, 2020
Hong Chen, St. Louis, MO (US);
Yaoheng Yang, St. Louis, MO (US);
Jeffrey Williamson, St. Louis, MO (US);
Hong Chen, St. Louis, MO (US);
Yaoheng Yang, St. Louis, MO (US);
Jeffrey Williamson, St. Louis, MO (US);
Washington University, St. Louis, MO (US);
Abstract
Systems and methods for monitoring and controlling delivery of a therapeutic compound to a brain of a subject using FUS-BBBD are disclosed. The method includes treating the brain of the subject with focused ultrasound in combination with microbubbles for blood-brain barrier disruption (FUS-BBBD), administering the therapeutic agent to the subject; and obtaining a map of a concentration of the therapeutic agent delivered to the brain of the subject using passive cavitation imaging (PCI). The delivery of focused sound may be modulated to match the map of the concentration of the therapeutic agent delivered to the brain of the subject to a desired spatial distribution of the therapeutic agent.