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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11785922 B1

PDFFull Text
Date of Patent:
Oct. 17, 2023

Filed:

May. 03, 2018

Recombinant vector comprising ert2 fused to cas9

Applicant:

Seoul National University Hospital, Seoul, KR;

Inventors:

Eun Ju Lee, Seoul, KR;

Hyo-Soo Kim, Seoul, KR;

Assignee:

SEOUL NATIONAL UNIVERSITY HOSPITAL, Seoul, KR;

Attorneys:

Vorys, Sater Seymour and Pease LLP

Mih Suhn Koh

Primary Examiner:

Amy M Bunker

Assistant Examiner:

Vyoma Shailesh Thakker

Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/113 (2010.01); C12N 15/85 (2006.01); C12N 15/09 (2006.01); A01K 67/027 (2006.01); C07K 14/72 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0275 (2013.01); C07K 14/72 (2013.01); C12N 9/22 (2013.01); C12N 15/113 (2013.01); C12N 15/8509 (2013.01); A01K 2217/07 (2013.01); A01K 2227/105 (2013.01); C07K 2319/09 (2013.01);
Abstract

Provided are a protein complex in which estrogen receptor 2 (-ERT2) is fused to CRISPR associated protein 9 (Cas9), and a recombinant vector carrying a gene coding the protein complex, wherein ERT2 is bonded to the N-terminus and C-terminus of nuclear localization sequence (NLS)-removed Cas9 and the complex has the advantage of translocating from the cytosol into the nucleus at a certain time point upon treatment with tamoxifen and modifying a specific DNA with the aid of guide RNA (gRNA), ultimately enabling a more elaborate DNA modification operation in a desired part at a desired time point.

Find Patent Forward Citations

Lee, Eun. (2023). Recombinant vector comprising ert2 fused to cas9 (U.S. Patent No. 11785922). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11785922

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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