The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 10, 2023

Filed:

Apr. 27, 2022
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Jacob J. Chabon, Arvada, CO (US);

David M. Kurtz, San Carlos, CA (US);

Maximilian Diehn, San Carlos, CA (US);

Arash Ash Alizadeh, San Mateo, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G16B 20/20 (2019.01); C12Q 1/6886 (2018.01); G16B 25/00 (2019.01); G16B 25/20 (2019.01); G16B 30/00 (2019.01); G16B 30/10 (2019.01); G16H 10/60 (2018.01); G16H 50/20 (2018.01); C12Q 1/6813 (2018.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
G16B 20/20 (2019.02); C12Q 1/6886 (2013.01); G16B 25/00 (2019.02); G16B 25/20 (2019.02); G16B 30/00 (2019.02); G16B 30/10 (2019.02); G16H 10/60 (2018.01); G16H 50/20 (2018.01); C12Q 1/6813 (2013.01); C12Q 1/6869 (2013.01); C12Q 2600/156 (2013.01);
Abstract

Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.


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