The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
Jun. 28, 2019
Applicant:
Trustees of Boston University, Boston, MA (US);
Inventors:
Ahmad S. Khalil, Lexington, MA (US);
Caleb J. Bashor, Boston, MA (US);
Nikit Patel, Brookline, MA (US);
James J. Collins, Newton, MA (US);
Assignee:
Trustees of Boston University, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/82 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8216 (2013.01); C07K 14/47 (2013.01); C07K 2319/81 (2013.01);
Abstract
Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.