The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
Mar. 03, 2020
Applicant:
Proqr Therapeutics Ii B.v., Leiden, NL;
Inventors:
Bart Klein, Leiden, NL;
Gerardus Johannes Platenburg, Leiden, NL;
Assignee:
ProQR Therapeutics II B.V., Leiden, NL;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/907 (2013.01); C12N 2310/11 (2013.01); C12N 2310/16 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3519 (2013.01); C12N 2310/531 (2013.01); C12N 2310/533 (2013.01);
Abstract
RNA editing is achieved using oligonucleotide constructs comprising (i) a targeting portion specific for a target nucleic acid sequence to be edited and (ii) a recruiting portion capable of binding and recruiting a nucleic acid editing entity naturally present in the cell. The nucleic acid editing entity, such as ADAR, is redirected to a preselected target site by means of the targeting portion, thereby promoting editing of preselected nucleotide residues in a region of the target RNA which corresponds to the targeting portion.