The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
Jun. 09, 2020
Pfizer Healthcare Ireland, Dublin, IE;
Olivier Alexandre Laurent, San Diego, CA (US);
Alice Lee, Poway, CA (US);
Richard Ryan Preston, Escondido, CA (US);
David Tumelty, San Diego, CA (US);
Wei Hong Yu, San Diego, CA (US);
Abhijit Suresh Bhat, Encinitas, CA (US);
Anna Tempczyk-Russell, San Diego, CA (US);
Pfizer Healthcare Ireland, Dublin, IE;
Abstract
The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β-strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X-X-X-X-KH(SEQ ID NO:98), and X, Xand Xare each independently any amino acid residue, characterized in that Xis selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof.