The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
Dec. 16, 2020
Applicant:
Scinopharm Taiwan, Ltd., Tainan, TW;
Inventors:
Assignee:
ScinoPharm Taiwan, Ltd., Tainan, TW;
Primary Examiner:
Int. Cl.
CPC ...
C07C 303/32 (2006.01); C07C 309/04 (2006.01); C07D 403/04 (2006.01); B01J 23/44 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); B01J 23/44 (2013.01); C07C 303/32 (2013.01); C07C 309/04 (2013.01);
Abstract
Provided herein are improved processes and methods for preparing osimertinib or a salt thereof, in particular osimertinib mesylate. The improved process removes the necessity of isolating the unstable aniline intermediate of formula (III) and enables the direct coupling to form the amide product of formula (II): The present invention is suitable for a large-scale production, avoiding the isolation of unstable intermediate, thereby providing osimertinib or a mesylate salt thereof in both high yields and high purity.