The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
May. 05, 2022
Texas Children's Hospital, Houston, TX (US);
Alzeca Biosciences, Llc, Houston, TX (US);
Eric A. Tanifum, Richmond, TX (US);
Xianwei Sun, Houston, TX (US);
Ananth V. Annapragada, Manvel, TX (US);
Carlo Medici, Reno, NV (US);
Texas Children's Hospital, Houston, TX (US);
Alzeca Biosciences, LLC, Houston, TX (US);
Abstract
A liposomal composition ('ADx-003') is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: wherein X is —CH—, —CH—CH—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or A and B are independently selected from C and N; R, R, R, and Rare independently selected from —H, halogen, —OH, and —CH; and R, R, and Rare independently selected from —H, halogen, —OH, —OCH, —NO, —N(CH), C-Calkyl, or a substituted or unsubstituted C-Caryl group, except that when A and/or B is N the adjacent Rand/or Ris —H, or a pharmaceutically acceptable salt thereof.