The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
Nov. 09, 2020
Hangzhou Dac Biotech Co., Ltd., Hangzhou, CN;
Robert Yongxin Zhao, Lexington, MA (US);
Robert Yongxin Zhao, Lexington, MA (US);
Qingliang Yang, Hangzhou, CN;
Yuanyuan Huang, Hangzhou, CN;
Shun Gai, Hangzhou, CN;
Linyao Zhao, Hangzhou, CN;
Hangbo Ye, Hangzhou, CN;
Huihui Guo, Hangzhou, CN;
Qianqian Tong, Hangzhou, CN;
Minjun Cao, Hangzhou, CN;
Junxiang Jia, Hangzhou, CN;
Chengyu Yang, Hangzhou, CN;
Wenjun Li, Hangzhou, CN;
Xiaomai Zhou, Hangzhou, CN;
Hongsheng Xie, Hangzhou, CN;
Chen Lin, Hangzhou, CN;
Zhixiang Guo, Hangzhou, CN;
Zhicang Ye, Hangzhou, CN;
HANGZHOU DAC BIOTECH CO., LTD., Hangzhou, CN;
Abstract
The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.