The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2023
Filed:
Sep. 27, 2018
The Regents of the University of California, Oakland, CA (US);
Huan Meng, Los Angeles, CA (US);
Melissa J. Spencer, Los Angeles, CA (US);
April D. Pyle, Los Angeles, CA (US);
Courtney S. Young, Los Angeles, CA (US);
Xiangsheng Liu, Los Angeles, CA (US);
Ying Ji, Los Angeles, CA (US);
Michael Reza Emami, Los Angeles, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.