The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 10, 2023

Filed:

Dec. 18, 2019
Applicant:

Novartis Ag, Basel, CH;

Inventors:

Matthew Burger, Belmont, MA (US);

Joseph Anthony D'Alessio, Boston, MA (US);

Tony Fleming, Stow, MA (US);

Vivek Rauniyar, Cambridge, MA (US);

Eusebio Manchado Robles, Basel, CH;

Christian Kunz, Planegg, DE;

Markus Waldhuber, Munich, DE;

Assignee:

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 31/4745 (2006.01); C07K 16/18 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 31/4745 (2013.01); A61P 35/00 (2018.01); C07K 16/18 (2013.01); A61K 45/06 (2013.01);
Abstract

This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates comprising antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The application also discloses methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.


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