The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
May. 19, 2021
Applicant:
Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Bing Chen, Westwood, MA (US);
Tianshu Xiao, Boston, MA (US);
Yongfei Cai, Boston, MA (US);
Jun Zhang, Boston, MA (US);
Assignee:
Children's Medical Center Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/48 (2006.01); C07K 14/36 (2006.01); G01N 33/569 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/485 (2013.01); C07K 14/36 (2013.01); C12Y 304/17023 (2013.01); G01N 33/56983 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); G01N 2333/165 (2013.01);
Abstract
Provided herein, in some aspects, are polypeptide monomers comprising an angiotensin-converting enzyme 2 (ACE2) ectodomain and an oligomerization domain. Also provided herein are oligomeric complexes comprising ACE2 monomers. Methods of using such to monomers and oligomeric complexes for the diagnosis, prevention, and treatment of viral infections such as the coronavirus are also provided.