The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
Jul. 12, 2018
Applicant:
National University Corporation Tokyo Medical and Dental University, Tokyo, JP;
Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01);
U.S. Cl.
CPC ...
C12N 5/066 (2013.01); A61L 27/225 (2013.01); A61L 27/3683 (2013.01); A61L 27/386 (2013.01); A61L 27/3834 (2013.01); A61L 2430/10 (2013.01); C12N 2506/45 (2013.01); C12N 2527/00 (2013.01); C12N 2533/54 (2013.01); C12N 2533/56 (2013.01);
Abstract
The present invention relates to providing artificial tendon or ligament tissue having sufficient strength. More specifically, artificial tendon or ligament tissue having sufficient strength is provided by embedding collagen-secreting cells in a gel having strength capable of resisting a tensile load and by culturing the cells while applying a tensile load to the gel to produce artificial tendon or ligament tissue. Cells that steadily express the Mkx gene can be used as the collagen-secreting cells. A fibrin gel containing aprotinin can be used as the gel.