The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
May. 06, 2020
Denali Therapeutics Inc., South San Francisco, CA (US);
Mark S. Dennis, South San Francisco, CA (US);
Jennifer A. Getz, South San Francisco, CA (US);
Rinkan Shukla, South San Francisco, CA (US);
Adam P. Silverman, South San Francisco, CA (US);
Yin Zhang, South San Francisco, CA (US);
Joy Yu Zuchero, South San Francisco, CA (US);
Denali Therapeutics Inc., South San Francisco, CA (US);
Abstract
In one aspect, antibodies that specifically bind to a human BACE1 protein are provided herein. In some embodiments, the antibodies contain modifications that reduce effector function, extend serum stability or serum half-life, or promote heterodimerization. In other aspects, bispecific antibodies and pharmaceutical compositions comprising antibodies that bind to human BACE1 protein are provided herein. Methods for inhibiting amyloid-β formation and/or aggregation, inhibiting amyloid plaque formation, and treating neurodegenerative diseases are also provided herein.