The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 03, 2023

Filed:

Aug. 20, 2020
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Corey Anderson, San Diego, CA (US);

Sara Sabina Hadida Ruah, LaJolla, CA (US);

Julian Marian Charles Golec, Abingdon, GB;

Beili Zhang, San Diego, CA (US);

Benjamin Joseph Littler, Carlsbad, CA (US);

Ali Keshavarz-Shokri, San Diego, CA (US);

Tim Edward Alcacio, San Diego, CA (US);

Daniel T. Belmont, Grafton, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/58 (2006.01); C07F 9/59 (2006.01); C07F 9/576 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07F 9/58 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07F 9/576 (2013.01); C07F 9/59 (2013.01);
Abstract

The invention relates to prodrug compounds of formula I: wherein R, R, R, Rand X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.


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