The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
Aug. 09, 2019
Yale University, New Haven, CT (US);
Ya Ha, Mamaroneck, NY (US);
Jonathan Ellman, Guilford, CT (US);
Song Chen, New Haven, CT (US);
Caroline Chandra Tjin, Boston, MA (US);
Fabrizio Micheli, Verona, IT;
Agostino Cianciulli, Verona, IT;
Claudia Beato, Verona, IT;
YALE UNIVERSITY, New Haven, CT (US);
Abstract
The present-disclosure relates to the discovery of novel 2-amino-dihydropteridinone compounds and analogues thereof, which are capable of inhibiting phosphatidylinositol phosphate kinases. In certain embodiments, the compounds of the present disclosure can be used to treat p53-null cancer in a subject. In other embodiments, the compounds of the present disclosure can be used to treat metabolic disorders in a subject, including but not limited to type 2 diabetes and/or obesity.