The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
May. 10, 2019
Glaxosmithkline Intellectual Property Development Limited, Brentford, GB;
Jeffrey Michael Axten, King of Prussia, PA (US);
Mui Cheung, King of Prussia, PA (US);
Michael P. Demartino, Collegeville, PA (US);
Huiping Amy Guan, Acton, MA (US);
Yan Hu, Shanghai, CN;
Aaron Bayne Miller, Research Triangle Park, NC (US);
Donghui Qin, Malvern, PA (US);
Chengde Wu, Shanghai, CN;
Zhiliu Zhang, Shanghai, CN;
Xiaojuan Lin, Shanghai, CN;
Glaxosmithkline Intellectual Property Development Limited, Brentford, GB;
Abstract
This invention relates to novel compounds according to Formula (I) which are inhibitors of furin, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of fibrotic diseases, including pulmonary fibrosis, renal fibrosis, liver fibrosis, skin fibrosis, ocular fibrosis, cardiac fibrosis, and other miscellaneous fibrotic conditions. The disclosed compounds may also be useful for treating other furin-mediated conditions, including but not limited to, hypertension, cancer, infectious diseases, and genetic disorders (e.g., cystic fibrosis (CF)), and neurodegenerative disorders.