The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11771720 B1

Date of Patent:

Oct. 03, 2023

Filed:

Aug. 29, 2019

Method for preparing immune-tolerized extracellular vesicle containing lactate dehydrogenase band peroxisome proliferator-activated receptor gamma coactivator 1-alpha, and composition comprising the extracellular vesicle

Applicant:

Stemmedicare Co., Ltd, Seoul, KR;

Inventor:

Jang Ho Lee, Seoul, KR;

Assignee:

STEMMEDICARE CO., LTD., Seoul, KR;

Attorney:

Maschoff Brennan

Primary Examiner:

Elly-Gerald Stoica

Int. Cl.

CPC ...

A61K 35/50 (2015.01); A61P 35/00 (2006.01); A61K 35/12 (2015.01);

U.S. Cl.

CPC ...

A61K 35/50 (2013.01); A61P 35/00 (2018.01); A61K 2035/122 (2013.01);

Abstract

The present invention relates to anticancer extracellular vesicles, a preparation method therefor, and an anticancer composition comprising same. Immune-tolerized extracellular vesicles containing LDHB and PGC-1α of the present invention provide cancer treatment, suppression of cancer metastasis, and cancer prevention technologies by normalizing cancer cell-specific aerobic glycolysis energy metabolic pathway in which lactate and hydrogen ions, which form a tumor microenvironment favorable for immune evasion, proliferation, metastasis and invasion of cancer cells, are produced, thereby enabling tumors to be effectively removed by means of the immune system of a patient.

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