The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2023
Filed:
Apr. 29, 2022
President and Fellows of Harvard College, Cambridge, MA (US);
Ping Xie, Needham, MA (US);
Charles M. Lieber, Lexington, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
To sense the translocation of a molecule through a nanopore, there is directed to an inlet of the nanopore, having a nanopore fluidic resistance, R, a molecule disposed in a cis fluidic ionic solution having a cis fluidic access resistance, R. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and to a trans fluidic ionic solution having a trans fluidic access resistance, R. The trans fluidic access resistance, R, is of the same order of magnitude as the nanopore fluidic resistance, R, and both Rand Rare at least an order of magnitude greater than the cis fluidic access resistance, R. An indication of local electrical potential is produced at a site within the nanopore sensor that is on the trans fluidic ionic solution-side of the nanopore, to sense translocation of the molecule through the nanopore.