The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2023
Filed:
Mar. 27, 2023
Applicant:
Genecraft Inc., Cheongju-si, KR;
Inventors:
Suk Chul Bae, Cheongju-si, KR;
You Soub Lee, Cheongju-si, KR;
Xinzi Chi, Cheongju-si, KR;
Ja Yeol Lee, Cheongju-si, KR;
Assignee:
GENECRAFT, INC., Cheongju-si, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/86 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61P 35/00 (2018.01); C12N 15/113 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Provided is an adeno-associated virus (AAV) complex for expression of an RUNX3 gene including an asymmetrically modified inverted terminal repeat (ITR). The AAV complex has asymmetric ITRs in which one of the two ITRs is modified, thereby increasing self-replication efficiency in host cells and increasing expression efficiency of a delivered gene, and therefore, compared to existing AAV complexes, the AAV complex has an advantage of improved productivity and gene expression efficiency.