The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2023
Filed:
Feb. 23, 2018
Rijksuniversiteit Groningen, Groningen, NL;
Academisch Ziekenhuis Groningen, Groningen, NL;
Patrick van Rijn, Groningen, NL;
Martin Conrad Harmsen, Groningen, NL;
Qihui Zhou, Groningen, NL;
Philipp Till Kuhn, Groningen, NL;
Gabriel Liguori, Groningen, NL;
RIJKSUNIVERSITEIT GRONINGEN, Groningen, NL;
ACADEMISCH ZIEKENHUIS GRONINGEN, Groningen, NL;
Abstract
The invention relates to the fields of biomaterials, tissue engineering and regenerative medicine. More specifically, it relates to biomaterial substrates having precise surface properties and the use thereof to investigate cell-material interactions. Provided is a cell culture system having a biomaterial substrate which has at least a first linear surface gradient oriented orthogonally to a second linear surface gradient, wherein the first gradient and the second gradient are selected from the group consisting of stiffness (S), (aligned) topography (T) and wettability (W). Also provided is a cell screening platform having a combination of at least two, preferably at least three, more preferably four distinct cell culture systems.